TY  - THES
T1  - Role of Stem Cell Factor in the Development of Alzheimer's Disease
A1  - Sopova,Kateryna
Y1  - 2012/09/26
N2  - Alzheimers disease (AD) is the most common cause of cognitive decline in the elderly and is characterized by massive neuronal cell loss in the brain. Stem cell factor (SCF) is a hematopoietic growth factor (HGF) that promotes
neuroprotective effects and supports neurogenesis in the brain. Decreased SCF plasma levels have been described in AD patients. Whether SCF plasma levels are also associated with the rate of cognitive decline in AD patients has not been reported so far. In the present study significantly lower SCF plasma levels (AD patients versus healthy controls: 908.5±181.7 pg/ml versus 1058.3 ±221.5 pg/ml) in AD patients were observed. Moreover, SCF plasma levels are significantly decreased in AD patients with fast cognitive decline compared to AD patients with slow cognitive decline. The results of the work suggest that  lower SCF plasma levels are associated with a higher rate of cognitive decline in AD patients. Thus, treatment strategies increasing SCF plasma levels could be useful for delaying the progression of AD and slowing the cognitive decline and in this way increasing the quality of life of AD  patients. 
KW  - Alzheimer-Krankheit
KW  - Demenz
KW  - Stammzellenfaktor
CY  - Tübingen
PB  - Universitätsbibliothek Tübingen
AD  - Wilhelmstr. 32, 72074 Tübingen
UR  - http://tobias-lib.uni-tuebingen.de/volltexte/2012/6428
ER  -