A novel glycosylated indolocarbazole derivative LCS1269 effectively inhibits growth of human cancer cells in vitro and in vivo through driving of both apoptosis and senescence by inducing of DNA damage and modulating of AKT/mTOR/S6K and ERK pathways

Kalitin, Nikolay N.; Ektova, Lidia V.; Kostritsa, Natalia S.; Sivirinova, Anastasia S.; Kostarev, Alexander V.; Smirnova, Galina B.; Borisova, Yulia A.; Golubeva, Irina S.; Ermolaeva, Elisaveta V.; Vergun, Maria A.; Babaeva, Maria A.; Lushnikova, Anna A.; Karamysheva, Aida F.

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A novel glycosylated indolocarbazole derivative LCS1269 effectively inhibits growth of human cancer cells in vitro and in vivo through driving of both apoptosis and senescence by inducing of DNA damage and modulating of AKT/mTOR/S6K and ERK pathways

Autor(en):

Kalitin, Nikolay N.; Ektova, Lidia V.; Kostritsa, Natalia S.; Sivirinova, Anastasia S.; Kostarev, Alexander V.; Smirnova, Galina B.; Borisova, Yulia A.; Golubeva, Irina S.; Ermolaeva, Elisaveta V.; Vergun, Maria A.; Babaeva, Maria A.; Lushnikova, Anna A.; Karamysheva, Aida F.

Tübinger Autor(en):

Kostarev, Alexander V.

Erschienen in:

Chemico - Biological Interactions (2022), Bd. 364, Article 110056

Verlagsangabe:

Elsevier Ireland Ltd

Sprache:

Englisch

Referenz zum Volltext:

http://dx.doi.org/10.1016/j.cbi.2022.110056

ISSN:

0009-2797