Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

Wittlinger, Florian; Ogboo, Blessing C.; Shevchenko, Ekaterina; Damghani, Tahereh; Pham, Calvin D.; Schaeffner, Ilse K.; Oligny, Brandon T.; Chitnis, Surbhi P.; Beyett, Tyler S.; Rasch, Alexander; Buckley, Brian; Urul, Daniel A.; Shaurova, Tatiana; May, Earl W.; Schaefer, Erik M.; Eck, Michael J.; Hershberger, Pamela A.; Poso, Antti; Laufer, Stefan A.; Heppner, David E.

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Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

Author:

Wittlinger, Florian; Ogboo, Blessing C.; Shevchenko, Ekaterina; Damghani, Tahereh; Pham, Calvin D.; Schaeffner, Ilse K.; Oligny, Brandon T.; Chitnis, Surbhi P.; Beyett, Tyler S.; Rasch, Alexander; Buckley, Brian; Urul, Daniel A.; Shaurova, Tatiana; May, Earl W.; Schaefer, Erik M.; Eck, Michael J.; Hershberger, Pamela A.; Poso, Antti; Laufer, Stefan A.; Heppner, David E.

Tübinger Autor(en):

Wittlinger, Florian
Shevchenko, Ekaterina
Rasch, Alexander
Poso, Antti
Laufer, Stefan

Published in:

Communications Chemistry (2024), Bd. 7 (1), Article 38

Verlagsangabe:

Berlin : Nature Portfolio

Language:

English

Full text:

http://dx.doi.org/10.1038/s42004-024-01108-3

ISSN:

2399-3669