Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis

Lim, Bryce; Kamal, Aryan; Gomez Ramos, Borja; Adrian Segarra, Juan M.; Ibarra, Ignacio L.; Dignas, Lennart; Kindinger, Tim; Volz, Kai; Rahbari, Mohammad; Rahbari, Nuh; Poisel, Eric; Kafetzopoulou, Kanela; Boese, Lio; Breinig, Marco; Heide, Danijela; Gallage, Suchira; Barragan Avila, Jose E.; Wiethoff, Hendrik; Berest, Ivan; Schnabellehner, Sarah; Schneider, Martin; Becker, Jonas; Helm, Dominic; Grimm, Dirk; Maekinen, Taija; Tschaharganeh, Darjus F.; Heikenwalder, Mathias; Zaugg, Judith B.; Mall, Moritz

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis

Author:

Lim, Bryce; Kamal, Aryan; Gomez Ramos, Borja; Adrian Segarra, Juan M.; Ibarra, Ignacio L.; Dignas, Lennart; Kindinger, Tim; Volz, Kai; Rahbari, Mohammad; Rahbari, Nuh; Poisel, Eric; Kafetzopoulou, Kanela; Boese, Lio; Breinig, Marco; Heide, Danijela; Gallage, Suchira; Barragan Avila, Jose E.; Wiethoff, Hendrik; Berest, Ivan; Schnabellehner, Sarah; Schneider, Martin; Becker, Jonas; Helm, Dominic; Grimm, Dirk; Maekinen, Taija; Tschaharganeh, Darjus F.; Heikenwalder, Mathias; Zaugg, Judith B.; Mall, Moritz

Tübinger Autor(en):

Gallage, Suchira
Heikenwälder, Mathias

Published in:

Nature Genetics (2025), Bd. 57, H. 3, S. 668–679

Verlagsangabe:

Berlin : Nature Portfolio

Language:

English

Full text:

http://dx.doi.org/10.1038/s41588-025-02081-w

ISSN:

1061-4036