Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties

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Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties

Author: Stopper, Daniel; Biermann, Lukas; Watson, Paris R.; Li, Jingyu; Koenig, Beate; Gaynes, Matthew N.; Pessanha de Carvalho, Lais; Klose, Jana; Hanl, Maria; Hamacher, Alexandra; Schaeker-Huebner, Linda; Ramsbeck, Daniel; Held, Jana; Christianson, David W.; Kassack, Matthias U.; Hansen, Finn K.
Tübinger Autor(en):
Pessanha de Carvalho, Lais
Held, Jana
Published in: Journal of Medicinal Chemistry (2025), Bd. 68, H. 4, S. 4426-4452
Verlagsangabe: Washington : Amer Chemical Soc
Language: English
Full text: http://dx.doi.org/10.1021/acs.jmedchem.4c02373
ISSN: 0022-2623
DDC Classifikation: 540 - Chemistry and allied sciences
Dokumentart: Article
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