Azapeptide-Based SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Enzyme Inhibition, Structural Determination, and Antiviral Activity

Flury, Philipp; Vishwakarma, Jyoti; Sylvester, Katharina; Higashi-Kuwata, Nobuyo; Dabrowska, Agnieszka K.; Delgado, Renee; Cuell, Ashley; Basu, Rahul; Taylor, Alexander B.; de Oliveira, Ellen Goncalves; Magalhaes Serafim, Mateus Sa; Qiao, Jingxin; Chen, Yan; Yang, Shengyong; O'Donoghue, Anthony J.; Mitsuya, Hiroaki; Guetschow, Michael; Laufer, Stefan A.; Mueller, Christa E.; Harris, Reuben S.; Pillaiyar, Thanigaimalai

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Azapeptide-Based SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Enzyme Inhibition, Structural Determination, and Antiviral Activity

Author:

Flury, Philipp; Vishwakarma, Jyoti; Sylvester, Katharina; Higashi-Kuwata, Nobuyo; Dabrowska, Agnieszka K.; Delgado, Renee; Cuell, Ashley; Basu, Rahul; Taylor, Alexander B.; de Oliveira, Ellen Goncalves; Magalhaes Serafim, Mateus Sa; Qiao, Jingxin; Chen, Yan; Yang, Shengyong; O'Donoghue, Anthony J.; Mitsuya, Hiroaki; Guetschow, Michael; Laufer, Stefan A.; Mueller, Christa E.; Harris, Reuben S.; Pillaiyar, Thanigaimalai

Tübinger Autor(en):

Flury, Philipp
Laufer, Stefan
Pillaiyar, Thanigaimalai

Published in:

Journal of Medicinal Chemistry (2025), Bd. 68, H. 18, S. 19339-19376

Verlagsangabe:

Washington : Amer Chemical Soc

Language:

English

Full text:

http://dx.doi.org/10.1021/acs.jmedchem.5c01520

ISSN:

0022-2623