Uridine Depletion and Chemical Modification Increase Cas9 mRNA Activity and Reduce Immunogenicity without HPLC Purification

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Uridine Depletion and Chemical Modification Increase Cas9 mRNA Activity and Reduce Immunogenicity without HPLC Purification

Author: Vaidyanathan, Sriram; Azizian, Krist T.; Haque, A. K. M. Ashiqul; Henderson, Jordana M.; Hendel, Ayal; Shore, Sabrina; Antony, Justin S.; Hogrefe, Richard, I; Kormann, Michael S. D.; Porteus, Matthew H.; McCaffrey, Anton P.
Tübinger Autor(en):
Haque, A. K. M. Ashiqul
Selvaraj, Justin Antony
Kormann, Michael
Published in: Molecular Therapy - Nucleic Acids (2018), Bd. 12, S. 530-542
Verlagsangabe: Cell Press
Language: English
Full text: http://dx.doi.org/10.1016/j.omtn.2018.06.010
ISSN: 2162-2531
DDC Classifikation: 610 - Medicine and health
Dokumentart: Article
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