Abstract:
In this thesis, new methods were developed for a better characterization of tissue by means of magnetic resonance imaging and magnetic resonance spectroscopy. First, a method is described for a better separation of the overlapping intra- and extramyocellular lipid signals in 1H magnetic resonance spectra by means of the calculation of the magnetic field distribution in the examined tissue area. Second, echo planar imaging was adapted and optimized for diffusion-weighted imaging of lower leg musculature in order to gain maximal signal and to avoid image distortions caused by eddy currents induced in the scanner by switching gradients for diffusion weighting. Finally, a method was implemented for measurement of diffusion of fat in the lower leg.